Clinical Pearls for Optometry Edition 2.1 - Chapter 3
Systemic Medications and Ocular Side Effects
A) Chloroquine derivatives
1) Chloroquine
a) Old antirheumatic drug
b) Still used for malaria
c) Cause depigmentation of macular retinal pigment epithelium (RPE) and bull’s eye maculopathy
d) Retinal damage usually appears after 100 grams cumulative dose
e) Monitor closely with baseline photos, frequent dilated exams, Amsler monocular color vision and macular vision field testing
f ) Meds for troops in Persian Gulf, Afghanistan
2) Hydroxychloroquine (Plaquenil)
a) Replaced chloroquine for arthritis treatment
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